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How to choose the valve used in the pharmaceutical industry
The valves required for pharmaceuticals need to be characterized to avoid cross-contamination and easy cleaning. Commonly used valves include globe valves, ball valves, butterfly valves, diaphragm valves, check valves, and the like.
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Different working functions and characteristics are available for different types of valves, and it is also necessary to select according to the type of application and the area used. Also consider factors such as switching frequency, pressure loss, regulation performance, and temperature, pressure, and media for specified process conditions.
The advantages and disadvantages of several common valves are listed below:
Advantages of the globe valve:
1: High frequency operation is possible
2: Can be used in high pressure environment
3: With good regulation performance
Disadvantages of the globe valve:
1: The medium pressure is too large to cause loss
2: Flow direction fixed
3: can only be used in liquid conditions
Advantages of the diaphragm valve:
1: High frequency operation is possible
2: Clean or contaminated media can be used
3: no dead ends
4: sterilizable
5: Cleanable
6: With good regulation performance
7: Flow direction selection
Disadvantages of diaphragm valves:
1: The medium pressure is too large to cause loss
2: higher cost and post-maintenance costs
3: Limited operating pressure and operating temperature
4: Fast wear
The advantages of the butterfly valve:
1: Pressure damage to the valve is low
2: Flow direction selection
3: compact structure, good quality and light weight
4: The cost is lower than other valves
The disadvantages of the butterfly valve:
1: low operating frequency
2: Poor adjustment performance
3: If the medium is granules, it will wear quickly.
4: Working pressure is suitable for medium and low pressure
Advantages of the ball valve:
1: relatively low cost
2: good sealing
3: round shape, almost no pressure loss
4: Flow direction selection
5: Can be used in high temperature and high pressure working conditions
Disadvantages of the ball valve:
1: low operating frequency
2: Poor adjustment performance
3: There is a closed corner when it is closed.
The EU GMP standard requires valves to meet the characteristics of avoiding cross-contamination and easy cleaning. In practice, FDA-approved diaphragm valves have become the designated valves in sterile applications, and FDA-approved globe valves are designated valves for clean room applications. In the case of aseptic applications, the FDA even explicitly specifies the need to use a diaphragm valve to ensure good cleaning of the equipment or system. Non-clean media for cooling water or heated steam mainly uses butterfly valves, ball valves and globe valves. These valves do not directly affect the quality of the products. These valves that are not in direct contact with the product are economically considered.
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